TY - JOUR AU - Sarkar , Prasenjit AU - Das , Saumyajyoti AU - Majee, Sutapa Biswas PY - 2022/11/05 Y2 - 2024/03/28 TI - In Vitro Studies on Binary Mixture of Skimmed Milk and Urea as Solid Dispersion Carrier for Aceclofenac JF - JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH JA - JOAASR VL - 4 IS - 4 SE - Articles DO - 10.46947/joaasr442022446 UR - http://joaasr.com/index.php/joaasr/article/view/446 SP - 9-18 AB - <p>Among the various strategies employed to enhance solubility, dissolution and bioavailability of poorly soluble drugs in vivo, formulation of solid dispersion using hydrophilic and/or water-soluble carriers with varying physicochemical characteristics seems to be a developable, economically viable and easy option. The present study is aimed to use skimmed milk(SKM)-urea(U) as a novel binary mixture of classical carrier-hydrotrope in solid dispersion of poorly water-soluble aceclofenac (ACF). Compatibility of ACF and binary mixture of SKM-U was confirmed by FTIR spectroscopic analysis. Solid dispersions of ACF-SKM and ACF-SKM-U were prepared in varying ratios of 1:1 to 1: 5 for ACF-SKM and 1:4.5:0.5, 1:4.25:0.75 and 1:4:1 for ACF-SKM-U by solvent evaporation technique using ethanol(95%) as the common solvent and were characterised by their physical appearance, solubility enhancement (compared to pure drug) in double distilled water and phosphate buffer (pH 6.8) at 25 ⁰C and drug dissolution profiles in the above mentioned media. Based on solubility enhancement data(71.53%&nbsp; and 31.03%) and maximum cumulative percentage release data (82.37% in 9 mins and 68.03% in 90 secs ) in double distilled water and phosphate buffer respectively, ACF-SKM (1:5) was found to the best which was used for studying the effect of addition of urea as hydrotrope. ACF: SKM: U (1 : 4.5 : 0.75) exhibited maximum solubility enhancement of 75% .and 36.51% and cumulative percentage release of 83.83 % in 9 mins and 69.24% in 90 secs in double distilled water and&nbsp; buffer respectively. Therefore, the binary mixture of skimmed milk-urea has been proved to be marginally superior over skimmed milk in terms of solubility enhancement and drug release profile of aceclofenac.</p> ER -